ea0090oc6.6 | Oral Communications 6: Endocrine-related Cancer | ECE2023
Altieri Barbara
, S. Tourigny David
, Secener Ali Kerim
, Sbiera Silviu
, Arampatzi Panagiota
, Sauer Sascha
, Fassnacht Martin
, Ronchi Cristina
Background: Molecular mechanisms of malignant adrenocortical tumorigenesis remain elusive despite previous comprehensive genomic studies. Nonetheless, cellular heterogeneity of primary, recurrent and metastatic adrenocortical carcinoma (ACC) havent been fully investigated.Aim: To characterize the molecular profile of different cell subtypes in primary, recurrent and metastatic ACC by single-nuclei RNA sequencing (snRNA-Seq), using adult human norma...